› 6ymb

Electron crystallography
2.5Å resolution

MicroED structure of human carbonic anhydrase II

Released:
DOI: 10.2210/pdb6ymb/pdb
PDB 6ymb coloured by chain and viewed from the front.
PDB 6ymb coloured by chain and viewed from the side.
PDB 6ymb coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Visualizing drug binding interactions using microcrystal electron diffraction.
Clabbers MTB, Fisher SZ, Coin��on M, Zou X, Xu H
Commun Biol 3 417 (2020)
PMID: 32737395

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Fragment-to-Lead Medicinal Chemistry Publications in 2020.
de Esch et al. (2022)
4 more