› 6um1

Electron Microscopy
3.46Å resolution

Structure of M-6-P/IGFII Receptor at pH 4.5

Released:
DOI: 10.2210/pdb6um1/pdb
PDB entry 6um1 coloured by chain, front view.
PDB entry 6um1 coloured by chain, side view.
PDB entry 6um1 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Wang R, Qi X, Schmiege P, Coutavas E, Li X
Sci Adv 6 eaaz1466- (2020)
Related structures: EMD-20815

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139951 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Cation-independent mannose-6-phosphate receptor Chain: A
Molecule details ›
Chain: A
Length: 2499 amino acids
Theoretical weight: 274.83 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P08169 (Residues: 1-2499; Coverage: 100%)
Gene names: IGF2R, M6P
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.46Å
Relevant EMDB volumes: EMD-20815

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