6scx

X-ray diffraction
2.92Å resolution

Crystal structure of the catalytic domain of human NUDT12 in complex with 7-methyl-guanosine-5'-triphosphate

Released:

Function and Biology Details

Reaction catalysed:
NAD(H) + H(2)O = AMP + NMN(H)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisomal NADH pyrophosphatase NUDT12 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 352 amino acids
Theoretical weight: 40 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BQG2 (Residues: 111-462; Coverage: 76%)
Gene name: NUDT12
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: R32
Unit cell:
a: 229.859Å b: 229.859Å c: 159.012Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.232 0.26
Expression system: Escherichia coli BL21(DE3)