› 6rz6

X-ray diffraction
2.43Å resolution

Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (C2221 space group)

Released:
DOI: 10.2210/pdb6rz6/pdb
PDB entry 6rz6 coloured by chain, front view.
PDB entry 6rz6 coloured by chain, side view.
PDB entry 6rz6 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V
OpenAccess logo Nat Commun 10 5573 (2019)
PMID: 31811124

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142145 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteinyl leukotriene receptor 2; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 405 amino acids
Theoretical weight: 46 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NS75 (Residues: 17-232, 240-322; Coverage: 86%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: CYSLT2, CYSLT2R, CYSLTR2, PSEC0146, cybC
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand KNW 1 x KNW
Ligand CLR 1 x CLR
Ligand TLA 1 x TLA
Ligand OLC 16 x OLC
Ligand OLA 10 x OLA
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29, ESRF BEAMLINE ID30B
Spacegroup: C2221
Unit cell:
a: 69.81Å b: 170.88Å c: 85.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.232
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.
Gilbert et al. (2021)
4 more

12 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
11 more