X-ray diffraction
1.73Å resolution

Crystal structure of the 19F labelled OXA-48


Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Beta-lactamase Chains: A, B
Molecule details ›
Chains: A, B
Length: 245 amino acids
Theoretical weight: 28.58 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli BL21
  • Canonical: Q6XEC0 (Residues: 23-265; Coverage: 100%)
Gene names: FNY87_29090, FOB39_00045, KPE71T_00045, bla OXA-48, blaOXA-48
Sequence domains: Penicillin binding protein transpeptidase domain

Ligands and Environments

2 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 64.36Å b: 58.03Å c: 66.43Å
α: 90° β: 91.49° γ: 90°
R R work R free
0.179 0.177 0.21
Expression system: Escherichia coli BL21