› 6pg6

X-ray diffraction
1.68Å resolution

WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acetamide

Released:
DOI: 10.2210/pdb6pg6/pdb
PDB entry 6pg6 coloured by chain, front view.
PDB entry 6pg6 coloured by chain, side view.
PDB entry 6pg6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fragment screening for a protein-protein interaction inhibitor to WDR5.
Dennis ML, Morrow BJ, Dolezal O, Cuzzupe AN, Stupple AE, Newman J, Bentley J, Hattarki M, Nuttall SD, Foitzik RC, Street IP, Stupple PA, Monahan BJ, Peat TS
Struct Dyn 6 064701 (2019)
PMID: 31768400

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158474 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 34.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand OH7 2 x OH7
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Unit cell:
a: 112.366Å b: 46.974Å c: 129.274Å
α: 90° β: 112.75° γ: 90°
R-values:
R R work R free
0.167 0.165 0.193
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

WD Repeat Domain 5 Inhibitors for Cancer Therapy: Not What You Think.
Weissmiller et al. (2024)
3 other articles

1 mention without citation

Fragment screening for a protein-protein interaction inhibitor to WDR5.
Dennis et al. (2019)