X-ray diffraction
1.9Å resolution

OXA-48 carbapanemase, doripenem complex


Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Beta-lactamase Chains: A, B
Molecule details ›
Chains: A, B
Length: 265 amino acids
Theoretical weight: 30.4 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli
  • Canonical: Q6XEC0 (Residues: 1-265; Coverage: 100%)
Gene names: FNY87_29090, FOB39_00045, KPE71T_00045, bla OXA-48, blaOXA-48
Sequence domains: Penicillin binding protein transpeptidase domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 72.604Å b: 76.749Å c: 101.188Å
α: 90° β: 90° γ: 90°
R R work R free
0.197 0.194 0.241
Expression system: Escherichia coli