6p67

X-ray diffraction
2.9Å resolution

Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Anti-IL-7R 2B8 Fab heavy chain Chains: A, C, E, H
Molecule details ›
Chains: A, C, E, H
Length: 225 amino acids
Theoretical weight: 24.27 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
anti-IL-7R 2B8 Fab light chain Chains: B, D, F, L
Molecule details ›
Chains: B, D, F, L
Length: 214 amino acids
Theoretical weight: 23.61 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Interleukin-7 receptor subunit alpha Chains: G, I, J, K
Molecule details ›
Chains: G, I, J, K
Length: 223 amino acids
Theoretical weight: 25.69 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P16871 (Residues: 21-239; Coverage: 50%)
Gene name: IL7R
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 84.9Å b: 219.68Å c: 90.35Å
α: 90° β: 104.328° γ: 90°
R-values:
R R work R free
0.249 0.249 0.266
Expression systems:
  • Homo sapiens
  • Drosophila melanogaster