X-ray diffraction
2.4Å resolution

Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor

Source organism: Homo sapiens
Entry authors: Halabelian L, Dong A, Zeng H, Loppnau P, Bountra C, Edwards AM, Arrowsmith CH, Brown PJ, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Histone-lysine N-methyltransferase SUV39H2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 299 amino acids
Theoretical weight: 33.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9H5I1 (Residues: 112-410; Coverage: 73%)
Gene names: KMT1B, SUV39H2
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 146.701Å b: 63.388Å c: 65.616Å
α: 90° β: 113.17° γ: 90°
R R work R free
0.215 0.212 0.267
Expression system: Escherichia coli BL21(DE3)