› 6olg

Electron Microscopy
3.4Å resolution

Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)

Released:
DOI: 10.2210/pdb6olg/pdb
PDB entry 6olg coloured by chain, front view.
PDB entry 6olg coloured by chain, side view.
PDB entry 6olg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Li W, Ward FR, McClure KF, Chang ST, Montabana E, Liras S, Dullea RG, Cate JHD
Nat Struct Mol Biol 26 501-509 (2019)
PMID: 31160784
Related structures: EMD-0601

Function and Biology Details

Reaction catalysed: 
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 85-mer (preferred)
PDBe Complex ID:
PDB-CPX-138654 (preferred)
Entry contents:
79 distinct polypeptide molecules
6 distinct RNA molecules
Macromolecules (85 distinct):
Large ribosomal subunit protein uL2 Chain: AA
Molecule details ›
Chain: AA
Length: 257 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62917 (Residues: 1-257; Coverage: 100%)
Gene name: RPL8
Sequence domains:
Small ribosomal subunit protein uS2 Chain: BA
Molecule details ›
Chain: BA
Length: 215 amino acids
Theoretical weight: 24.25 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08865 (Residues: 5-219; Coverage: 73%)
Gene names: LAMBR, LAMR1, RPSA
Sequence domains: Ribosomal protein S2
Large ribosomal subunit protein uL3 Chain: AB
Molecule details ›
Chain: AB
Length: 394 amino acids
Theoretical weight: 45.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39023 (Residues: 2-395; Coverage: 98%)
Gene names: OK/SW-cl.32, RPL3
Sequence domains: Ribosomal protein L3
Small ribosomal subunit protein eS1 Chain: BB
Molecule details ›
Chain: BB
Length: 212 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61247 (Residues: 22-233; Coverage: 80%)
Gene names: FTE1, MFTL, RPS3A
Sequence domains: Ribosomal S3Ae family
Large ribosomal subunit protein uL4 Chain: AC
Molecule details ›
Chain: AC
Length: 363 amino acids
Theoretical weight: 41.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P36578 (Residues: 3-365; Coverage: 85%)
Gene names: RPL1, RPL4
Sequence domains:
Small ribosomal subunit protein uS5 Chain: BC
Molecule details ›
Chain: BC
Length: 222 amino acids
Theoretical weight: 24.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P15880 (Residues: 57-278; Coverage: 76%)
Gene names: RPS2, RPS4
Sequence domains:
Large ribosomal subunit protein uL18 Chain: AD
Molecule details ›
Chain: AD
Length: 294 amino acids
Theoretical weight: 34.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46777 (Residues: 4-297; Coverage: 99%)
Gene names: MSTP030, RPL5
Sequence domains:
Large ribosomal subunit protein eL6 Chain: AE
Molecule details ›
Chain: AE
Length: 194 amino acids
Theoretical weight: 22.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02878 (Residues: 95-288; Coverage: 67%)
Gene names: RPL6, TXREB1
Sequence domains: Ribosomal protein L6e
Large ribosomal subunit protein uL30 Chain: AF
Molecule details ›
Chain: AF
Length: 234 amino acids
Theoretical weight: 27.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18124 (Residues: 15-248; Coverage: 94%)
Gene name: RPL7
Sequence domains:
Large ribosomal subunit protein eL8 Chain: AG
Molecule details ›
Chain: AG
Length: 234 amino acids
Theoretical weight: 26.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62424 (Residues: 29-262; Coverage: 88%)
Gene names: RPL7A, SURF-3, SURF3
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 Chain: AH
Molecule details ›
Chain: AH
Length: 191 amino acids
Theoretical weight: 21.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P32969 (Residues: 1-191; Coverage: 100%)
Gene names: OK/SW-cl.103, RPL9, RPL9P7, RPL9P8, RPL9P9
Sequence domains: Ribosomal protein L6
Large ribosomal subunit protein uL16 Chain: AI
Molecule details ›
Chain: AI
Length: 211 amino acids
Theoretical weight: 24.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P27635 (Residues: 3-213; Coverage: 99%)
Gene names: DXS648E, QM, RPL10
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: AJ
Molecule details ›
Chain: AJ
Length: 169 amino acids
Theoretical weight: 19.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62913 (Residues: 9-177; Coverage: 95%)
Gene name: RPL11
Sequence domains:
Large ribosomal subunit protein uL10 Chain: AK
Molecule details ›
Chain: AK
Length: 109 amino acids
Theoretical weight: 12.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05388 (Residues: 1-109; Coverage: 34%)
Gene name: RPLP0
Sequence domains: Ribosomal protein L10
Large ribosomal subunit protein eL13 Chain: AL
Molecule details ›
Chain: AL
Length: 205 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P26373 (Residues: 2-206; Coverage: 97%)
Gene names: BBC1, OK/SW-cl.46, RPL13
Sequence domains: Ribosomal protein L13e
Large ribosomal subunit protein eL14 Chain: AM
Molecule details ›
Chain: AM
Length: 139 amino acids
Theoretical weight: 16.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50914 (Residues: 2-140; Coverage: 65%)
Gene name: RPL14
Sequence domains: Ribosomal protein L14
Large ribosomal subunit protein eL15 Chain: AN
Molecule details ›
Chain: AN
Length: 203 amino acids
Theoretical weight: 24.08 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61313 (Residues: 2-204; Coverage: 100%)
Gene names: EC45, RPL15, TCBAP0781
Sequence domains: Ribosomal L15
Large ribosomal subunit protein uL13 Chain: AO
Molecule details ›
Chain: AO
Length: 195 amino acids
Theoretical weight: 22.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P40429 (Residues: 5-199; Coverage: 96%)
Gene name: RPL13A
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL22 Chain: AP
Molecule details ›
Chain: AP
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18621 (Residues: 2-154; Coverage: 83%)
Gene name: RPL17
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein eL18 Chain: AQ
Molecule details ›
Chain: AQ
Length: 187 amino acids
Theoretical weight: 21.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q07020 (Residues: 2-188; Coverage: 100%)
Gene name: RPL18
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
Large ribosomal subunit protein eL19 Chain: AR
Molecule details ›
Chain: AR
Length: 181 amino acids
Theoretical weight: 21.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P84098 (Residues: 2-182; Coverage: 92%)
Gene name: RPL19
Sequence domains: Ribosomal protein L19e
Large ribosomal subunit protein eL20 Chain: AS
Molecule details ›
Chain: AS
Length: 175 amino acids
Theoretical weight: 20.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02543 (Residues: 1-175; Coverage: 99%)
Gene name: RPL18A
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL21 Chain: AT
Molecule details ›
Chain: AT
Length: 157 amino acids
Theoretical weight: 18.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46778 (Residues: 2-158; Coverage: 98%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
Large ribosomal subunit protein eL22 Chain: AU
Molecule details ›
Chain: AU
Length: 99 amino acids
Theoretical weight: 11.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P35268 (Residues: 18-116; Coverage: 77%)
Gene name: RPL22
Sequence domains: Ribosomal L22e protein family
Large ribosomal subunit protein uL14 Chain: AV
Molecule details ›
Chain: AV
Length: 129 amino acids
Theoretical weight: 13.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62829 (Residues: 12-140; Coverage: 92%)
Gene name: RPL23
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein eL24 Chain: AW
Molecule details ›
Chain: AW
Length: 121 amino acids
Theoretical weight: 14.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83731 (Residues: 2-122; Coverage: 77%)
Gene name: RPL24
Sequence domains: Ribosomal protein L24e
Large ribosomal subunit protein uL23 Chain: AX
Molecule details ›
Chain: AX
Length: 117 amino acids
Theoretical weight: 13.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62750 (Residues: 39-155; Coverage: 75%)
Gene name: RPL23A
Sequence domains:
Large ribosomal subunit protein uL24 Chain: AY
Molecule details ›
Chain: AY
Length: 127 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61254 (Residues: 1-127; Coverage: 88%)
Gene name: RPL26
Sequence domains:
Large ribosomal subunit protein eL27 Chain: AZ
Molecule details ›
Chain: AZ
Length: 134 amino acids
Theoretical weight: 15.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61353 (Residues: 3-136; Coverage: 99%)
Gene name: RPL27
Sequence domains:
Large ribosomal subunit protein uL15 Chain: Aa
Molecule details ›
Chain: Aa
Length: 147 amino acids
Theoretical weight: 16.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46776 (Residues: 2-148; Coverage: 99%)
Gene name: RPL27A
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: Ab
Molecule details ›
Chain: Ab
Length: 121 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P47914 (Residues: 2-122; Coverage: 76%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: Ac
Molecule details ›
Chain: Ac
Length: 103 amino acids
Theoretical weight: 11.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62888 (Residues: 7-109; Coverage: 90%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: Ad
Molecule details ›
Chain: Ad
Length: 106 amino acids
Theoretical weight: 12.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62899 (Residues: 18-123; Coverage: 85%)
Gene name: RPL31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: Ae
Molecule details ›
Chain: Ae
Length: 129 amino acids
Theoretical weight: 15.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62910 (Residues: 2-130; Coverage: 96%)
Gene names: PP9932, RPL32
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL33 Chain: Af
Molecule details ›
Chain: Af
Length: 109 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18077 (Residues: 2-110; Coverage: 99%)
Gene names: GIG33, RPL35A
Sequence domains: Ribosomal protein L35Ae
Large ribosomal subunit protein eL34 Chain: Ag
Molecule details ›
Chain: Ag
Length: 114 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49207 (Residues: 2-115; Coverage: 97%)
Gene name: RPL34
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: Ah
Molecule details ›
Chain: Ah
Length: 122 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42766 (Residues: 2-123; Coverage: 99%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
Large ribosomal subunit protein eL36 Chain: Ai
Molecule details ›
Chain: Ai
Length: 97 amino acids
Theoretical weight: 11.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3U8 (Residues: 5-101; Coverage: 92%)
Gene name: RPL36
Sequence domains: Ribosomal protein L36e
Large ribosomal subunit protein eL37 Chain: Aj
Molecule details ›
Chain: Aj
Length: 84 amino acids
Theoretical weight: 9.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61927 (Residues: 2-85; Coverage: 87%)
Gene name: RPL37
Sequence domains: Ribosomal protein L37e
Large ribosomal subunit protein eL38 Chain: Ak
Molecule details ›
Chain: Ak
Length: 69 amino acids
Theoretical weight: 8.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63173 (Residues: 2-70; Coverage: 99%)
Gene name: RPL38
Sequence domains: Ribosomal L38e protein family
Large ribosomal subunit protein eL39 Chain: Al
Molecule details ›
Chain: Al
Length: 50 amino acids
Theoretical weight: 6.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62891 (Residues: 2-51; Coverage: 98%)
Gene name: RPL39
Sequence domains: Ribosomal L39 protein
Large ribosomal subunit protein eL40 Chain: Am
Molecule details ›
Chain: Am
Length: 50 amino acids
Theoretical weight: 5.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62987 (Residues: 78-127; Coverage: 39%)
Gene names: UBA52, UBCEP2
Sequence domains: Ribosomal L40e family
Small ribosomal subunit protein eS32 Chain: An
Molecule details ›
Chain: An
Length: 25 amino acids
Theoretical weight: 3.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62945 (Residues: 1-25; Coverage: 100%)
Gene name: RPL41
Sequence domains: Ribosomal protein L41
Large ribosomal subunit protein eL42 Chain: Ao
Molecule details ›
Chain: Ao
Length: 105 amino acids
Theoretical weight: 12.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83881 (Residues: 2-106; Coverage: 99%)
Gene names: GIG15, MIG6, RPL36A, RPL44
Sequence domains: Ribosomal protein L44
Large ribosomal subunit protein eL43 Chain: Ap
Molecule details ›
Chain: Ap
Length: 91 amino acids
Theoretical weight: 10.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61513 (Residues: 2-92; Coverage: 99%)
Gene name: RPL37A
Sequence domains: Ribosomal L37ae protein family
Large ribosomal subunit protein uL11 Chain: Aq
Molecule details ›
Chain: Aq
Length: 138 amino acids
Theoretical weight: 14.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P30050 (Residues: 7-144; Coverage: 84%)
Gene name: RPL12
Sequence domains:
Large ribosomal subunit protein eL28 Chain: At
Molecule details ›
Chain: At
Length: 122 amino acids
Theoretical weight: 13.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46779 (Residues: 2-123; Coverage: 89%)
Gene name: RPL28
Sequence domains: Ribosomal L28e protein family
Large ribosomal subunit protein uL1 Chain: Au
Molecule details ›
Chain: Au
Length: 217 amino acids
Theoretical weight: 24.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62906 (Residues: 1-217; Coverage: 100%)
Gene names: NEDD6, RPL10A
Sequence domains: Ribosomal protein L1p/L10e family
Small ribosomal subunit protein uS3 Chain: BD
Molecule details ›
Chain: BD
Length: 220 amino acids
Theoretical weight: 24.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P23396 (Residues: 2-221; Coverage: 91%)
Gene names: OK/SW-cl.26, RPS3
Sequence domains:
Small ribosomal subunit protein eS4, Y isoform 1 Chain: BE
Molecule details ›
Chain: BE
Length: 257 amino acids
Theoretical weight: 28.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P22090 (Residues: 2-258; Coverage: 98%)
Gene names: PRO2646, RPS4Y, RPS4Y1
Sequence domains:
Small ribosomal subunit protein uS7 Chain: BF
Molecule details ›
Chain: BF
Length: 190 amino acids
Theoretical weight: 21.42 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46782 (Residues: 15-204; Coverage: 93%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein eS6 Chain: BG
Molecule details ›
Chain: BG
Length: 232 amino acids
Theoretical weight: 26.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62753 (Residues: 1-232; Coverage: 93%)
Gene names: OK/SW-cl.2, RPS6
Sequence domains: Ribosomal protein S6e
Small ribosomal subunit protein eS7 Chain: BH
Molecule details ›
Chain: BH
Length: 183 amino acids
Theoretical weight: 20.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62081 (Residues: 12-194; Coverage: 94%)
Gene name: RPS7
Sequence domains: Ribosomal protein S7e
Small ribosomal subunit protein eS8 Chain: BI
Molecule details ›
Chain: BI
Length: 207 amino acids
Theoretical weight: 24.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62241 (Residues: 2-208; Coverage: 100%)
Gene names: OK/SW-cl.83, RPS8
Sequence domains: Ribosomal protein S8e
Small ribosomal subunit protein uS4 Chain: BJ
Molecule details ›
Chain: BJ
Length: 179 amino acids
Theoretical weight: 21.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46781 (Residues: 2-180; Coverage: 92%)
Gene name: RPS9
Sequence domains:
Small ribosomal subunit protein eS10 Chain: BK
Molecule details ›
Chain: BK
Length: 98 amino acids
Theoretical weight: 11.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46783 (Residues: 1-98; Coverage: 59%)
Gene name: RPS10
Sequence domains: Plectin/S10 domain
Small ribosomal subunit protein uS17 Chain: BL
Molecule details ›
Chain: BL
Length: 153 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62280 (Residues: 6-158; Coverage: 97%)
Gene name: RPS11
Sequence domains:
Small ribosomal subunit protein eS12 Chain: BM
Molecule details ›
Chain: BM
Length: 120 amino acids
Theoretical weight: 13.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25398 (Residues: 11-130; Coverage: 91%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein uS15 Chain: BN
Molecule details ›
Chain: BN
Length: 149 amino acids
Theoretical weight: 17.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62277 (Residues: 2-150; Coverage: 99%)
Gene name: RPS13
Sequence domains:
Small ribosomal subunit protein uS11 Chain: BO
Molecule details ›
Chain: BO
Length: 136 amino acids
Theoretical weight: 14.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62263 (Residues: 16-151; Coverage: 90%)
Gene names: PRO2640, RPS14
Sequence domains: Ribosomal protein S11
Small ribosomal subunit protein uS19 Chain: BP
Molecule details ›
Chain: BP
Length: 120 amino acids
Theoretical weight: 14.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62841 (Residues: 12-131; Coverage: 83%)
Gene names: RIG, RPS15
Sequence domains: Ribosomal protein S19
Small ribosomal subunit protein uS9 Chain: BQ
Molecule details ›
Chain: BQ
Length: 139 amino acids
Theoretical weight: 15.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62249 (Residues: 8-146; Coverage: 95%)
Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein eS17 Chain: BR
Molecule details ›
Chain: BR
Length: 125 amino acids
Theoretical weight: 14.45 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08708 (Residues: 2-126; Coverage: 93%)
Gene names: RPS17, RPS17L
Sequence domains: Ribosomal S17
Small ribosomal subunit protein uS13 Chain: BS
Molecule details ›
Chain: BS
Length: 139 amino acids
Theoretical weight: 16.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62269 (Residues: 4-142; Coverage: 91%)
Gene names: D6S218E, RPS18
Sequence domains: Ribosomal protein S13/S18
Small ribosomal subunit protein eS19 Chain: BT
Molecule details ›
Chain: BT
Length: 143 amino acids
Theoretical weight: 15.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39019 (Residues: 2-144; Coverage: 99%)
Gene name: RPS19
Sequence domains: Ribosomal protein S19e
Small ribosomal subunit protein uS10 Chain: BU
Molecule details ›
Chain: BU
Length: 97 amino acids
Theoretical weight: 11.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60866 (Residues: 20-116; Coverage: 82%)
Gene name: RPS20
Sequence domains: Ribosomal protein S10p/S20e
Small ribosomal subunit protein eS21 Chain: BV
Molecule details ›
Chain: BV
Length: 81 amino acids
Theoretical weight: 8.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63220 (Residues: 1-81; Coverage: 98%)
Gene name: RPS21
Sequence domains: Ribosomal protein S21e
Small ribosomal subunit protein uS8 Chain: BW
Molecule details ›
Chain: BW
Length: 129 amino acids
Theoretical weight: 14.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62244 (Residues: 2-130; Coverage: 99%)
Gene names: OK/SW-cl.82, RPS15A
Sequence domains: Ribosomal protein S8
Small ribosomal subunit protein uS12 Chain: BX
Molecule details ›
Chain: BX
Length: 139 amino acids
Theoretical weight: 15.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62266 (Residues: 2-140; Coverage: 97%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
Small ribosomal subunit protein eS24 Chain: BY
Molecule details ›
Chain: BY
Length: 125 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62847 (Residues: 4-128; Coverage: 94%)
Gene name: RPS24
Sequence domains: Ribosomal protein S24e
Small ribosomal subunit protein eS25 Chain: BZ
Molecule details ›
Chain: BZ
Length: 86 amino acids
Theoretical weight: 9.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62851 (Residues: 28-113; Coverage: 69%)
Gene name: RPS25
Sequence domains: S25 ribosomal protein
Small ribosomal subunit protein eS26 Chain: Ba
Molecule details ›
Chain: Ba
Length: 97 amino acids
Theoretical weight: 11.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62854 (Residues: 2-98; Coverage: 84%)
Gene name: RPS26
Sequence domains: Ribosomal protein S26e
Small ribosomal subunit protein eS27 Chain: Bb
Molecule details ›
Chain: Bb
Length: 80 amino acids
Theoretical weight: 9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42677 (Residues: 4-83; Coverage: 95%)
Gene names: MPS1, RPS27
Sequence domains: Ribosomal protein S27
Small ribosomal subunit protein eS28 Chain: Bc
Molecule details ›
Chain: Bc
Length: 62 amino acids
Theoretical weight: 7.01 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62857 (Residues: 7-68; Coverage: 90%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
Small ribosomal subunit protein uS14 Chain: Bd
Molecule details ›
Chain: Bd
Length: 51 amino acids
Theoretical weight: 6.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62273 (Residues: 5-55; Coverage: 91%)
Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e
Small ribosomal subunit protein eS30 Chain: Be
Molecule details ›
Chain: Be
Length: 55 amino acids
Theoretical weight: 6.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62861 (Residues: 77-131; Coverage: 41%)
Gene name: FAU
Sequence domains: Ribosomal protein S30
Small ribosomal subunit protein eS31 Chain: Bf
Molecule details ›
Chain: Bf
Length: 73 amino acids
Theoretical weight: 8.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62979 (Residues: 79-151; Coverage: 47%)
Gene names: RPS27A, UBA80, UBCEP1
Sequence domains: Ribosomal protein S27a
Small ribosomal subunit protein RACK1 Chain: Bg
Molecule details ›
Chain: Bg
Length: 314 amino acids
Theoretical weight: 34.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63244 (Residues: 2-315; Coverage: 99%)
Gene names: GNB2L1, HLC7, PIG21, RACK1
Sequence domains: WD domain, G-beta repeat
E-Cad/CTF1 Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 4.04 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P12830 (Residues: 693-697, 698-730; Coverage: 4%)
Gene names: CDH1, CDHE, UVO
5.8S ribosomal RNA Chain: A3
Molecule details ›
Chain: A3
Length: 157 nucleotides
Theoretical weight: 50.45 KDa
Sequence domains: 5.8S ribosomal RNA
5S ribosomal RNA Chain: A4
Molecule details ›
Chain: A4
Length: 119 nucleotides
Theoretical weight: 38.39 KDa
Sequence domains: 5S ribosomal RNA
28S ribosomal RNA Chain: A2
Molecule details ›
Chain: A2
Length: 3612 nucleotides
Theoretical weight: 1170.16 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
18S Ribosomal RNA Chain: B1
Molecule details ›
Chain: B1
Length: 1708 nucleotides
Theoretical weight: 551.11 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA
tRNA Chain: Bv
Molecule details ›
Chain: Bv
Length: 76 nucleotides
Theoretical weight: 24.49 KDa
Sequence domains: tRNA
Messenger RNA Chain: Bx
Molecule details ›
Chain: Bx
Length: 16 nucleotides
Theoretical weight: 4.85 KDa

Ligands and Environments

3 bound ligands:
Ligand MG 326 x MG
Ligand ZN 5 x ZN
Ligand MVM 1 x MVM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0601

Quick links

Citations

10 review citations

Translational gene regulation in plants: A green new deal.
Urquidi Camacho et al. (2020)
9 more

3 mentions without citation

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Li et al. (2019)
2 more