6nmw

X-ray diffraction
1.2Å resolution

Crystal structure of the human Lyn SH3 domain

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lyn Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 8.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07948 (Residues: 63-125; Coverage: 12%)
Gene names: JTK8, LYN
Sequence domains: SH3 domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P61
Unit cell:
a: 46.722Å b: 46.722Å c: 55.696Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.172 0.183
Expression system: Escherichia coli BL21(DE3)