X-ray diffraction
1.65Å resolution

Designed repeat protein specifically in complex with Fz7CRD


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Designed repeat binding protein Chain: B
Molecule details ›
Chain: B
Length: 200 amino acids
Theoretical weight: 20.96 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
Structure domains: Ankyrin repeat-containing domain
Frizzled-7 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.11 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: O75084 (Residues: 46-163; Coverage: 22%)
Gene name: FZD7
Sequence domains: Fz domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Unit cell:
a: 57.604Å b: 68.367Å c: 86.468Å
α: 90° β: 90° γ: 90°
R R work R free
0.161 0.16 0.186
Expression systems:
  • Escherichia coli
  • Trichoplusia ni