PDBe 6ne2

X-ray diffraction
1.3Å resolution

Designed repeat protein in complex with Fz7

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Designed repeat protein binder Chain: B
Molecule details ›
Chain: B
Length: 200 amino acids
Theoretical weight: 20.93 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
Frizzled-7 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.11 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75084 (Residues: 46-163; Coverage: 22%)
Gene name: FZD7
Sequence domains: Fz domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Unit cell:
a: 57.61Å b: 68.04Å c: 86.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.184
Expression systems:
  • Escherichia coli
  • Trichoplusia ni