X-ray diffraction
3.01Å resolution

Designed repeat protein in complex with Fz4


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Frizzled-4 Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.62 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: Q9ULV1 (Residues: 42-161; Coverage: 24%)
Gene name: FZD4
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain
Pfs, NACHT and Ankyrin domain protein Chain: B
Molecule details ›
Chain: B
Length: 192 amino acids
Theoretical weight: 19.95 KDa
Source organism: Aspergillus fumigatus Af293
Expression system: Escherichia coli
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Unit cell:
a: 51.846Å b: 62.611Å c: 86.217Å
α: 90° β: 90° γ: 90°
R R work R free
0.24 0.234 0.293
Expression systems:
  • Trichoplusia ni
  • Escherichia coli