X-ray diffraction
2.26Å resolution

Designed repeat protein in complex with Fz8


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Frizzled-8 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 125 amino acids
Theoretical weight: 14.6 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
  • Canonical: Q9H461 (Residues: 32-150; Coverage: 18%)
Gene name: FZD8
Sequence domains: Fz domain
Designed repeat binding protein Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 200 amino acids
Theoretical weight: 20.86 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 79.93Å b: 109.015Å c: 114.373Å
α: 90° β: 90° γ: 90°
R R work R free
0.213 0.212 0.238
Expression systems:
  • Trichoplusia ni
  • Escherichia coli