PDBe 6nda

X-ray diffraction
3.15Å resolution

RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM

Released:
Entry authors: Stetefeld J, McDougall MD, Loewen PC

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Snaclec rhodocetin subunit gamma Chains: A, D, G, J, M, P
Molecule details ›
Chains: A, D, G, J, M, P
Length: 135 amino acids
Theoretical weight: 15.74 KDa
Source organism: Calloselasma rhodostoma
UniProt:
  • Canonical: D2YW39 (Residues: 1-135; Coverage: 100%)
Sequence domains: Lectin C-type domain
Snaclec rhodocetin subunit delta Chains: B, E, H, K, N, Q
Molecule details ›
Chains: B, E, H, K, N, Q
Length: 124 amino acids
Theoretical weight: 14.88 KDa
Source organism: Calloselasma rhodostoma
UniProt:
  • Canonical: D2YW40 (Residues: 1-124; Coverage: 100%)
Sequence domains: Lectin C-type domain
Integrin alpha-2 Chains: C, F, I, L, O, R
Molecule details ›
Chains: C, F, I, L, O, R
Length: 217 amino acids
Theoretical weight: 23.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17301 (Residues: 170-366; Coverage: 17%)
Gene names: CD49B, ITGA2
Sequence domains: von Willebrand factor type A domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU R-AXIS IV
Spacegroup: P41
Unit cell:
a: 130.53Å b: 130.53Å c: 250.919Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.271
Expression system: Escherichia coli