PDBe 6n4q

Electron Microscopy
3.6Å resolution

CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 12-mer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Ion transport protein; Sodium channel protein type 9 subunit alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 288 amino acids
Theoretical weight: 33.45 KDa
Source organisms: Expression system: Trichoplusia ni
  • Canonical: A8EVM5 (Residues: 1-25, 58-80, 108-267; Coverage: 78%)
  • Canonical: Q15858 (Residues: 758-788, 813-843; Coverage: 3%)
  • nullnull
Gene names: Abu_1752, NENA, SCN9A
Sequence domains: Ion transport protein
Beta/omega-theraphotoxin-Tp2a Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 30 amino acids
Theoretical weight: 3.84 KDa
Source organism: Thrixopelma pruriens
Expression system: Not provided
  • Canonical: P83476 (Residues: 1-30; Coverage: 100%)
Fab light chain Chains: I, K
Molecule details ›
Chains: I, K
Length: 215 amino acids
Theoretical weight: 23.48 KDa
Source organism: Mus musculus
Fab heavy chain Chains: J, L
Molecule details ›
Chains: J, L
Length: 228 amino acids
Theoretical weight: 24.52 KDa
Source organism: Mus musculus

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-0341
Expression systems:
  • Trichoplusia ni
  • Not provided