PDBe 6mok

X-ray diffraction
5.1Å resolution

Dimeric DARPin A_distance_R7 complex with EpoR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dimeric DARPin ANR7 (A_distance_r7) Chain: A
Molecule details ›
Chain: A
Length: 296 amino acids
Theoretical weight: 30.74 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Erythropoietin receptor Chain: B
Molecule details ›
Chain: B
Length: 229 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19235 (Residues: 32-249; Coverage: 45%)
Gene name: EPOR
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6222
Unit cell:
a: 117.09Å b: 117.09Å c: 233.587Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.225 0.299
Expression systems:
  • Escherichia coli
  • Trichoplusia ni