PDBe 6moj

X-ray diffraction
2.43Å resolution

Dimeric DARPin A_angle_R5 complex with EpoR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dimeric DARPin ACR5 (A_angle_R5) Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 24.26 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Erythropoietin receptor Chain: B
Molecule details ›
Chain: B
Length: 229 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19235 (Residues: 32-249; Coverage: 45%)
Gene name: EPOR
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: I4122
Unit cell:
a: 130.418Å b: 130.418Å c: 293.453Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.25
Expression systems:
  • Escherichia coli
  • Trichoplusia ni