PDBe 6mof

X-ray diffraction
2.89Å resolution

Monomeric DARPin G2 complex with EpoR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G2 DARPin Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 17.75 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Erythropoietin receptor Chain: B
Molecule details ›
Chain: B
Length: 229 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19235 (Residues: 32-249; Coverage: 45%)
Gene name: EPOR
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P41212
Unit cell:
a: 108.834Å b: 108.834Å c: 96.264Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.224 0.266
Expression systems:
  • Escherichia coli
  • Trichoplusia ni