PDBe 6moe

X-ray diffraction
2.09Å resolution

Monomeric DARPin E2 complex with EpoR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
E2 DARPin Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 17.97 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Erythropoietin receptor Chains: C, D
Molecule details ›
Chains: C, D
Length: 229 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P19235 (Residues: 32-249; Coverage: 45%)
Gene name: EPOR
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 69.25Å b: 122.16Å c: 132.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.23
Expression systems:
  • Escherichia coli
  • Trichoplusia ni