PDBe 6j8j

Electron Microscopy
3.2Å resolution

Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (Y1755 down)

Released:
Source organism: Homo sapiens
Primary publication:
Structures of human Na
Science (2019)
PMID: 30765606
Related structures: EMD-9782

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium channel subunit beta-2 Chain: C
Molecule details ›
Chain: C
Length: 215 amino acids
Theoretical weight: 24.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60939 (Residues: 1-215; Coverage: 100%)
Gene names: SCN2B, UNQ326/PRO386
Sequence domains: Immunoglobulin V-set domain
Sodium channel protein type 9 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 2031 amino acids
Theoretical weight: 231.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15858 (Residues: 1-1988; Coverage: 100%)
Gene names: NENA, SCN9A
Sequence domains:
Sodium channel subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 218 amino acids
Theoretical weight: 24.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07699 (Residues: 1-218; Coverage: 100%)
Gene name: SCN1B
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-9782
Expression system: Homo sapiens