6j8e

Electron Microscopy
3Å resolution

Human Nav1.2-beta2-KIIIA ternary complex

Released:
Source organisms:
Primary publication:
Molecular basis for pore blockade of human Na
Science (2019)
PMID: 30765605
Related structures: EMD-9780

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium channel subunit beta-2 Chain: C
Molecule details ›
Chain: C
Length: 122 amino acids
Theoretical weight: 14.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60939 (Residues: 27-148; Coverage: 64%)
Gene names: SCN2B, UNQ326/PRO386
Sequence domains: Immunoglobulin V-set domain
Sodium channel protein type 2 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 2048 amino acids
Theoretical weight: 232.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99250 (Residues: 1-2005; Coverage: 100%)
Gene names: NAC2, SCN2A, SCN2A1, SCN2A2
Sequence domains:
Mu-conotoxin KIIIA Chain: D
Molecule details ›
Chain: D
Length: 16 amino acids
Theoretical weight: 1.9 KDa
Source organism: Conus kinoshitai
Expression system: Not provided
UniProt:
  • Canonical: P0C195 (Residues: 5-20; Coverage: 73%)

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-9780
Expression systems:
  • Homo sapiens
  • Not provided