› 6ipo

X-ray diffraction
3Å resolution

Ferritin mutant C90A/C102A/C130A/D144C

Released:
DOI: 10.2210/pdb6ipo/pdb
PDB entry 6ipo coloured by chain, front view.
PDB entry 6ipo coloured by chain, side view.
PDB entry 6ipo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages.
Zang J, Chen H, Zhang X, Zhang C, Guo J, Du M, Zhao G
Nat Commun 10 778 (2019)
PMID: 30770832

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 48-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 176 amino acids
Theoretical weight: 20.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 96%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

1 bound ligand:
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: F432
Unit cell:
a: 236.229Å b: 236.229Å c: 236.229Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.245
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Protein Assembly by Design.
Zhu et al. (2021)
6 more