6ipc

X-ray diffraction
4.44Å resolution

Non-native human ferritin 8-mer

Released:

Function and Biology Details

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ferritin heavy chain Chains: A, B, C, E, F, G, H, I, J, K, M, N, O, P
Molecule details ›
Chains: A, B, C, E, F, G, H, I, J, K, M, N, O, P
Length: 176 amino acids
Theoretical weight: 20.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 96%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain
Ferritin heavy chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 176 amino acids
Theoretical weight: 20.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 96%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P1
Unit cell:
a: 52.304Å b: 139.223Å c: 139.114Å
α: 90.1° β: 90.28° γ: 90.18°
R-values:
R R work R free
0.21 0.207 0.277
Expression system: Escherichia coli