› 6i8l

X-ray diffraction
1.58Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195334 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spindlin-1 Chain: B
Molecule details ›
Chain: B
Length: 222 amino acids
Theoretical weight: 25.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y657 (Residues: 48-262; Coverage: 82%)
Gene names: OCR, SPIN, SPIN1
Sequence domains: Spin/Ssty Family

Ligands and Environments

5 bound ligands:
Ligand MPD 1 x MPD
Ligand MRD 1 x MRD
Ligand DMS 1 x DMS
Ligand H7Q 1 x H7Q
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P43212
Unit cell:
a: 115.35Å b: 115.35Å c: 43.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.207
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Targeting epigenetic protein-protein interactions with small-molecule inhibitors.
Linhares et al. (2020)
3 more