PDBe 6i3f

X-ray diffraction
2.55Å resolution

Crystal structure of the complex of human angiotensinogen and renin at 2.55 Angstrom

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Angiotensinogen Chain: A
Molecule details ›
Chain: A
Length: 458 amino acids
Theoretical weight: 50.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01019 (Residues: 34-485; Coverage: 100%)
Gene names: AGT, SERPINA8
Sequence domains: Serpin (serine protease inhibitor)
Renin Chain: B
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P6322
Unit cell:
a: 124.119Å b: 124.119Å c: 260.911Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.234
Expression system: Homo sapiens