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Human STK10 bound to Foretinib

X-ray diffraction
2.56Å resolution
PDB entry 6i2y coloured by chain, front view.
PDB entry 6i2y coloured by chain, side view.
PDB entry 6i2y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase 10
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Multimeric state: homo dimer
Accessible surface area: 26777.17 Å2
Buried surface area: 3069.76 Å2
Dissociation area: 1,534.88 Å2
Dissociation energy (ΔGdiss): 16.03 kcal/mol
Dissociation entropy (TΔSdiss): 13.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-131760

Macromolecules

Serine/threonine-protein kinase 10
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Pfam: Protein kinase domain
InterPro:
Serine/threonine-protein kinase 10 in PDB entry 6i2y, assembly 1, front view.
Serine/threonine-protein kinase 10 in PDB entry 6i2y, assembly 1, side view.
Serine/threonine-protein kinase 10 in PDB entry 6i2y, assembly 1, top view.
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