X-ray diffraction
1.75Å resolution

Human AURKC INCENP complex bound to BRD-7880

Source organism: Homo sapiens
Entry authors: Abdul Azeez KR, Sorrell FJ, von Delft F, Bountra C, Knapp S, Edwards AM, Arrowsmith C, Elkins JM

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aurora kinase C Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 32.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9UQB9 (Residues: 36-305; Coverage: 87%)
Gene names: AIE2, AIK3, AIRK3, ARK3, AURKC, STK13
Sequence domains: Protein kinase domain
Structure domains:
Inner centromere protein Chain: B
Molecule details ›
Chain: B
Length: 70 amino acids
Theoretical weight: 8.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9NQS7 (Residues: 835-903; Coverage: 8%)
Gene name: INCENP

Ligands and Environments

1 bound ligand:
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 56.65Å b: 72.48Å c: 83.06Å
α: 90° β: 90° γ: 90°
R R work R free
0.178 0.176 0.216
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli