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1.2 A resolution structure of human hydroxyacid oxidase 1 bound with FMN and 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole

X-ray diffraction
1.2Å resolution
PDB entry 6gmc coloured by chain, front view.
PDB entry 6gmc coloured by chain, side view.
PDB entry 6gmc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 2-Hydroxyacid oxidase 1
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Multimeric state: homo tetramer
Accessible surface area: 46143.28 Å2
Buried surface area: 17571.35 Å2
Dissociation area: 5,928.47 Å2
Dissociation energy (ΔGdiss): 36.81 kcal/mol
Dissociation entropy (TΔSdiss): 43.3 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-193816

Macromolecules

2-Hydroxyacid oxidase 1
Chain: A
Length: 368 amino acids
Theoretical weight: 40.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJM8 (Residues: 1-362; Coverage: 98%)
Gene names: GOX1, HAO1
Pfam: FMN-dependent dehydrogenase
InterPro:
CATH: Aldolase class I
2-Hydroxyacid oxidase 1 in PDB entry 6gmc, assembly 1, front view.
2-Hydroxyacid oxidase 1 in PDB entry 6gmc, assembly 1, side view.
2-Hydroxyacid oxidase 1 in PDB entry 6gmc, assembly 1, top view.
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