X-ray diffraction
1.95Å resolution

14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein sigma Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Sequence domains: 14-3-3 protein
Potassium channel subfamily K member 9 Chain: P
Molecule details ›
Chain: P
Length: 7 amino acids
Theoretical weight: 879 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9NPC2 (Residues: 368-374; Coverage: 2%)
Gene names: KCNK9, TASK3

Ligands and Environments

3 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-003
Spacegroup: C2221
Unit cell:
a: 82.453Å b: 111.473Å c: 63.675Å
α: 90° β: 90° γ: 90°
R R work R free
0.184 0.181 0.231
Expression systems:
  • Escherichia coli
  • Not provided