PDBe 6ge4

X-ray diffraction
1.97Å resolution

TEAD4 (216-434);E263A COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 1.97A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional enhancer factor TEF-3 Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 25.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15561 (Residues: 216-434; Coverage: 51%)
Gene names: RTEF1, TCF13L1, TEAD4, TEF3
Sequence domains: YAP binding domain
Transcriptional coactivator YAP1 Chain: L
Molecule details ›
Chain: L
Length: 41 amino acids
Theoretical weight: 4.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46937 (Residues: 60-100; Coverage: 8%)
Gene names: YAP1, YAP65

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P41212
Unit cell:
a: 59.033Å b: 59.033Å c: 159.129Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.241
Expression system: Escherichia coli BL21