PDBe 6fn1

Electron Microscopy
3.58Å resolution

Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)

Source organisms:
Related structures: EMD-4281

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Multidrug resistance protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1249 amino acids
Theoretical weight: 137.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P08183 (Residues: 32-1279; Coverage: 98%)
Gene names: ABCB1, MDR1, PGY1
Sequence domains:
UIC2 Antigen Binding Fragment Light chain Chain: B
Molecule details ›
Chain: B
Length: 220 amino acids
Theoretical weight: 24.32 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UIC2 Antigen Binding Fragment Heavy Chain Chain: C
Molecule details ›
Chain: C
Length: 225 amino acids
Theoretical weight: 24.38 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.58Å
Relevant EMDB volumes: EMD-4281
Expression systems:
  • Homo sapiens
  • Mus musculus