Solution NMR

NMR solution structure of monomeric CCL5 in complex with a doubly-sulfated N-terminal segment of CCR5


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C-C chemokine receptor type 5 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 3.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P51681 (Residues: 1-27; Coverage: 8%)
Gene names: CCR5, CMKBR5
C-C motif chemokine 5 Chain: B
Molecule details ›
Chain: B
Length: 69 amino acids
Theoretical weight: 7.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P13501 (Residues: 24-91; Coverage: 100%)
Gene names: CCL5, D17S136E, SCYA5
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: distance geometry
Chemical shifts: BMR34232  
Expression systems:
  • Not provided
  • Escherichia coli