6fcz

Electron Microscopy
10Å resolution

Model of gC1q-Fc complex based on 7A EM map

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C1q subcomponent subunit A Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02745 (Residues: 112-244; Coverage: 60%)
Gene name: C1QA
Sequence domains: C1q domain
Complement C1q subcomponent subunit B Chain: B
Molecule details ›
Chain: B
Length: 132 amino acids
Theoretical weight: 15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02746 (Residues: 119-250; Coverage: 58%)
Gene name: C1QB
Sequence domains: C1q domain
Complement C1q subcomponent subunit C Chain: C
Molecule details ›
Chain: C
Length: 129 amino acids
Theoretical weight: 14.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02747 (Residues: 117-245; Coverage: 59%)
Gene names: C1QC, C1QG
Sequence domains: C1q domain
Immunoglobulin gamma-1 heavy chain Chains: H, K
Molecule details ›
Chains: H, K
Length: 216 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 234-449; Coverage: 48%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 10Å
Relevant EMDB volumes: EMD-4232
Expression system: Homo sapiens