6eit

Electron Microscopy
3.9Å resolution

Coxsackievirus A24v in complex with the D1-D2 fragment of ICAM-1

Released:

Function and Biology Details

Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero 240-mer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
VP1 Chain: 1
Molecule details ›
Chain: 1
Length: 305 amino acids
Theoretical weight: 34.38 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 581-885; Coverage: 14%)
Sequence domains: picornavirus capsid protein
VP2 Chain: 2
Molecule details ›
Chain: 2
Length: 271 amino acids
Theoretical weight: 29.82 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 70-340; Coverage: 12%)
Sequence domains: picornavirus capsid protein
VP3 Chain: 3
Molecule details ›
Chain: 3
Length: 240 amino acids
Theoretical weight: 26.64 KDa
Source organism: Coxsackievirus A24
UniProt:
  • Canonical: V9VEF3 (Residues: 341-580; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Intercellular adhesion molecule 1 Chain: 4
Molecule details ›
Chain: 4
Length: 85 amino acids
Theoretical weight: 9.3 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05362 (Residues: 28-112; Coverage: 17%)
Gene name: ICAM1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-3880
Expression system: Cricetulus griseus