PDBe 6e7s

X-ray diffraction
2.72Å resolution

Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-5

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 385 amino acids
Theoretical weight: 43.16 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni
UniProt: Gene name: grin1
Sequence domains: Receptor family ligand binding region
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 363 amino acids
Theoretical weight: 41.28 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q00960 (Residues: 32-394; Coverage: 25%)
Gene name: Grin2b
Sequence domains: Receptor family ligand binding region

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-2
Spacegroup: C2
Unit cell:
a: 268.43Å b: 60.633Å c: 145.391Å
α: 90° β: 116.42° γ: 90°
R-values:
R R work R free
0.191 0.189 0.234
Expression system: Trichoplusia ni