6e3k

X-ray diffraction
3.25Å resolution

Interferon gamma signalling complex with IFNGR1 and IFNGR2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interferon gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 148 amino acids
Theoretical weight: 17.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01579 (Residues: 24-156; Coverage: 93%)
Gene name: IFNG
Interferon gamma receptor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 242 amino acids
Theoretical weight: 27.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15260 (Residues: 18-246; Coverage: 49%)
  • Best match: P15260-2 (Residues: 18-174)
Gene name: IFNGR1
Interferon gamma receptor 2 Chains: E, I
Molecule details ›
Chains: E, I
Length: 233 amino acids
Theoretical weight: 26.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P38484 (Residues: 28-247; Coverage: 70%)
Gene names: IFNGR2, IFNGT1
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 78.284Å b: 151.464Å c: 211.301Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.232
Expression systems:
  • Trichoplusia ni
  • Homo sapiens