6dnq

X-ray diffraction
2.35Å resolution

HBZ77 in complex with KIX and c-Myb

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
BZIP factor Chain: E
Molecule details ›
Chain: E
Length: 79 amino acids
Theoretical weight: 8.73 KDa
Source organism: Human T-cell leukemia virus type I
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2Q067 (Residues: 3-77; Coverage: 36%)
Gene name: HBZ
Transcriptional activator Myb Chains: A, C
Molecule details ›
Chains: A, C
Length: 32 amino acids
Theoretical weight: 3.81 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P06876 (Residues: 284-315; Coverage: 5%)
Gene name: Myb
Histone lysine acetyltransferase CREBBP Chains: B, D
Molecule details ›
Chains: B, D
Length: 88 amino acids
Theoretical weight: 10.49 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P45481 (Residues: 586-672; Coverage: 4%)
Gene names: Cbp, Crebbp
Sequence domains: KIX domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2
Unit cell:
a: 118.825Å b: 51.166Å c: 72.047Å
α: 90° β: 126.41° γ: 90°
R-values:
R R work R free
0.2 0.199 0.229
Expression system: Escherichia coli