PDBe 6dg5

X-ray diffraction
2.52Å resolution

Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neoleukin-2/15 Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 12.11 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Interleukin-2 receptor subunit beta Chain: B
Molecule details ›
Chain: B
Length: 209 amino acids
Theoretical weight: 24.47 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P16297 (Residues: 27-235; Coverage: 41%)
Gene name: Il2rb
Sequence domains: Interleukin-2 receptor subunit beta N-terminal domain 1
Cytokine receptor common subunit gamma Chain: C
Molecule details ›
Chain: C
Length: 199 amino acids
Theoretical weight: 23.8 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P34902 (Residues: 56-254; Coverage: 57%)
Gene name: Il2rg
Sequence domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Unit cell:
a: 65.125Å b: 67.914Å c: 172.084Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.221 0.266
Expression systems:
  • Escherichia coli
  • Trichoplusia ni