6d0s

X-ray diffraction
2.3Å resolution

RabGAP domain of human TBC1D22B

Released:
Source organism: Homo sapiens
Entry authors: Tong Y, Tempel W, Arrowsmith CH, Edwards AM, Bountra C, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TBC1 domain family member 22B Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 41.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NU19 (Residues: 178-505; Coverage: 65%)
Gene names: C6orf197, TBC1D22B
Sequence domains: Rab-GTPase-TBC domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P6522
Unit cell:
a: 78.015Å b: 78.015Å c: 217.699Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.239
Expression system: Escherichia coli BL21(DE3)