PDBe 6c4s

X-ray diffraction
1.5Å resolution

Human cSrc SH3 Domain in complex with Choline Kinase fragment 60-69

Released:
Source organism: Homo sapiens
Entry authors: Kall SL, Lavie A

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 74 amino acids
Theoretical weight: 8.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12931 (Residues: 87-144; Coverage: 11%)
Gene names: SRC, SRC1
Sequence domains: SH3 domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 31.117Å b: 38.753Å c: 57.966Å
α: 90° β: 95.7° γ: 90°
R-values:
R R work R free
0.189 0.187 0.226
Expression system: Escherichia coli