X-ray diffraction
2.5Å resolution

Complex structure of FAK FAT domain and DCC P3 motif


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Focal adhesion kinase 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 126 amino acids
Theoretical weight: 14.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P34152 (Residues: 921-1046; Coverage: 12%)
Gene names: Fadk, Fak, Fak1, Kiaa4203, Ptk2
Netrin receptor DCC Chains: B, D
Molecule details ›
Chains: B, D
Length: 23 amino acids
Theoretical weight: 2.45 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
  • Canonical: Q63155 (Residues: 1421-1443; Coverage: 2%)
Gene name: Dcc

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 129.178Å b: 36.13Å c: 65.429Å
α: 90° β: 104.3° γ: 90°
R R work R free
0.228 0.226 0.269
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided