X-ray diffraction
2.97Å resolution

MEF2 Chimera D83V mutant/DNA complex


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Myocyte-specific enhancer factor 2A; Myocyte-specific enhancer factor 2B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 95 amino acids
Theoretical weight: 11.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q02078 (Residues: 9-72, 92-95; Coverage: 13%)
  • Canonical: Q02080 (Residues: 1-8, 73-91; Coverage: 7%)
Gene names: MEF2, MEF2A, MEF2B, XMEF2
Sequence domains: SRF-type transcription factor (DNA-binding and dimerisation domain)
Structure domains: Transcription factor, MADS-box
DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3') Chains: E, G
Molecule details ›
Chains: E, G
Length: 14 nucleotides
Theoretical weight: 4.29 KDa
Molecule details ›
Chains: F, H
Length: 15 nucleotides
Theoretical weight: 4.57 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P32
Unit cell:
a: 78.44Å b: 78.44Å c: 111.041Å
α: 90° β: 90° γ: 120°
R R work R free
0.141 0.139 0.19
Expression system: Escherichia coli