PDBe 6bqh

X-ray diffraction
2.7Å resolution

Crystal structure of 5-HT2C in complex with ritanserin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-hydroxytryptamine receptor 2C; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 51.31 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P28335 (Residues: 40-245, 301-393; Coverage: 70%)
  • nullnull
Gene names: HTR1C, HTR2C, cybC
Sequence domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C222
Unit cell:
a: 88.31Å b: 97.05Å c: 150.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.254 0.253 0.274
Expression system: Spodoptera frugiperda