PDBe 6bq1

Electron Microscopy
3.6Å resolution

Human PI4KIIIa lipid kinase complex

Released:
Source organism: Homo sapiens
Related structures: EMD-7129

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Phosphatidylinositol 4-kinase alpha Chain: A
Molecule details ›
Chain: A
Length: 1647 amino acids
Theoretical weight: 173.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42356 (Residues: 932-2102; Coverage: 56%)
Gene names: PI4KA, PIK4, PIK4CA
Sequence domains:
Tetratricopeptide repeat protein 7B Chains: B, F
Molecule details ›
Chains: B, F
Length: 863 amino acids
Theoretical weight: 96.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q86TV6 (Residues: 1-843; Coverage: 100%)
Gene names: TTC7B, TTC7L1
Sequence domains:
Hyccin Chains: C, G
Molecule details ›
Chains: C, G
Length: 292 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYI3 (Residues: 2-289; Coverage: 55%)
Gene names: DRCTNNB1A, FAM126A
Phosphatidylinositol 4-kinase alpha Chain: E
Molecule details ›
Chain: E
Length: 1648 amino acids
Theoretical weight: 173.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42356 (Residues: 932-2102; Coverage: 56%)
Gene names: PI4KA, PIK4, PIK4CA
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-7129
Expression system: Homo sapiens