PDBe 6ak3

X-ray diffraction
2.9Å resolution

Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Prostaglandin E2 receptor EP3 subtype; Soluble cytochrome b562 Chains: A, B
Molecule details ›
Chains: A, B
Length: 418 amino acids
Theoretical weight: 46.04 KDa
Source organisms: Expression system: Spodoptera frugiperda
  • Canonical: P0ABE7 (Residues: 23-62, 85-127; Coverage: 78%)
  • Canonical: P43115 (Residues: 43-359; Coverage: 81%)
  • nullnull
Gene names: PTGER3, cybC
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: P21
Unit cell:
a: 66.09Å b: 42.28Å c: 161.3Å
α: 90° β: 96.09° γ: 90°
R R work R free
0.253 0.251 0.295
Expression system: Spodoptera frugiperda