Electron Microscopy
4.5Å resolution

Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-bound conformation 3


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1203 amino acids
Theoretical weight: 133.76 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Spodoptera frugiperda
  • Canonical: P59594 (Residues: 1-1196; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Processed angiotensin-converting enzyme 2 Chain: D
Molecule details ›
Chain: D
Length: 603 amino acids
Theoretical weight: 69.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q9BYF1 (Residues: 19-615; Coverage: 76%)
  • Best match: Q9BYF1-2 (Residues: 19-555)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.5Å
Relevant EMDB volumes: EMD-9594
Expression system: Spodoptera frugiperda