PDBe 6a90

Electron Microscopy
2.8Å resolution

Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana and Dc1a


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium channel protein PaFPC1 Chain: A
Molecule details ›
Chain: A
Length: 1596 amino acids
Theoretical weight: 183.88 KDa
Source organism: Periplaneta americana
Expression system: Homo sapiens
  • Canonical: D0E0C2 (Residues: 1-1553; Coverage: 100%)
Sequence domains:
Mu-diguetoxin-Dc1a Chain: B
Molecule details ›
Chain: B
Length: 57 amino acids
Theoretical weight: 6.5 KDa
Source organism: Diguetia canities
Expression system: Escherichia coli
  • Canonical: P49126 (Residues: 39-94; Coverage: 73%)
Sequence domains: Spider Toxins mu-diguetoxin-1 a, b and c

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-6995
Expression systems:
  • Homo sapiens
  • Escherichia coli