› 5zro

X-ray diffraction
1.41Å resolution

M. smegmatis antimutator protein MutT2 in complex with 5mdCTP

Released:
DOI: 10.2210/pdb5zro/pdb
PDB 5zro coloured by chain and viewed from the front.
PDB 5zro coloured by chain and viewed from the side.
PDB 5zro coloured by chain and viewed from the top.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
Structural insights into the specificity and catalytic mechanism of mycobacterial nucleotide pool sanitizing enzyme MutT2.
Singh A, Mohammad Arif S, Biak Sang P, Varshney U, Vijayan M
J. Struct. Biol. 204 449-456 (2018)
PMID: 30312643

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nudix hydrolase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 150 amino acids
Theoretical weight: 16.08 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli
UniProt:
  • Canonical: A0R2K6 (Residues: 1-130; Coverage: 100%)
Gene name: MSMEG_5148
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

2 bound ligands:
Ligand 523 2 x 523
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 31.61Å b: 72.76Å c: 57.86Å
α: 90° β: 104.7° γ: 90°
R-values:
R R work R free
0.143 0.141 0.184
Expression system: Escherichia coli

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